Evidence over hype

The Skip List

32 supplements and tactics the evidence says most people can stop paying for. Ranked worst value first, from our hand-reviewed worth-it verdicts. Every "Why" links to the full evidence review. How these scores work →

Flip it around: the Best Bets, ranked best value first →

1
Garcinia cambogia / HCA — Worth Your Money?
Weight Loss and Appetite
Poor ROI · 18/100 · Trust D
Why
2
Turkesterone
Muscle Building Claims
Poor ROI · 20/100 · Trust D
Why
3
Seed Oils — Evidence vs Controversy
General Nutrition / Inflammation
Poor ROI · 25/100 · Trust B
Why
4
Spot Reduction Truly Impossible
Fat Loss in a Specific Area (Belly, Arms, Thighs, Hips)
Poor ROI · 25/100 · Trust B
Why
5
1200 Calorie Diets — Why They Backfire
Fat Loss for the Broad Adult Population
Poor ROI · 28/100 · Trust B
Why
6
Text Neck
Neck Pain Management and Posture Concerns
Poor ROI · 28/100 · Trust A
Why
7
Core Stability
Low Back Pain Management — Core Training Decision
Poor ROI · 30/100 · Trust A
Why
8
CLA (Conjugated Linoleic Acid)
Fat Loss and Body Composition
Poor ROI · 30/100 · Trust D
9
Boron — Testosterone, Bone Health, Real Evidence
Bone, Hormones, and Joint Health
Poor ROI · 32/100 · Trust D
Why
10
CBD (Cannabidiol)
Anxiety, Pain, and Sleep
Poor ROI · 32/100 · Trust D
Why
11
Carnitine — Fat Transport, Who Benefits
Fat Loss and Exercise Performance
Low ROI · 42/100 · Trust C
Why
12
Spermidine
Longevity and Cellular Renewal
Low ROI · 42/100 · Trust D
Why
13
PQQ
Mitochondrial and Cognitive Support
Low ROI · 43/100 · Trust D
Why
14
NMN
Longevity and Healthy Aging
Low ROI · 44/100 · Trust D
Why
15
Green Tea Extract / EGCG
Fat Loss and Metabolic Health
Low ROI · 44/100 · Trust C
Why
16
HMB — Muscle Retention in Deficit
Muscle Preservation and Recovery
Low ROI · 44/100 · Trust D
Why
17
Lion's Mane — Does It Actually Work?
Cognition, Memory, and Nerve Health
Low ROI · 44/100 · Trust D
Why
18
Capsaicin / Capsaicinoids
Fat Loss, Metabolism, and Appetite
Low ROI · 44/100 · Trust C
Why
19
Resveratrol
Longevity and Cardiovascular Health
Low ROI · 45/100 · Trust D
Why
20
Chromium — Blood Sugar, Insulin Sensitivity, Weight Loss
Blood Sugar and Appetite
Low ROI · 45/100 · Trust C
Why
21
Post-Workout Nutrition — What Matters, What Doesn't
Hypertrophy and Recovery — Post-Workout Timing Decision
Low ROI · 48/100 · Trust A
Why
22
MCT Oil
Fat Loss, Energy, and Ketogenic Support
Low ROI · 48/100 · Trust C
Why
23
B-Complex Vitamins — Evidence Review
Energy, Stress, and General Health
Low ROI · 50/100 · Trust B
Why
24
Calcium — Bone Density, Heart Risk Debate
Bone Health and Osteoporosis
Low ROI · 50/100 · Trust C
Why
25
Vitamin C
Immune Health, Cold Duration, and General Health
Low ROI · 52/100 · Trust B
Why
26
Adaptogens Overview
Stress and General Resilience
Low ROI · 52/100 · Trust C
Why
27
Spirulina — Evidence Review
General Nutrition and Antioxidant Support
Low ROI · 52/100 · Trust C
Why
28
Quercetin
Immune, Allergy, and Anti-inflammatory Support
Low ROI · 53/100 · Trust C
Why
29
Selenium
Thyroid, Antioxidant, and Immune Support
Situational ROI · 55/100 · Trust C
Why
30
Alcohol Before Bed — The One-Drink Effect
Sleep Quality and Recovery
Situational ROI · 56/100 · Trust A
Why
31
NAC (N-Acetylcysteine)
Antioxidant, Liver, and Respiratory Support
Situational ROI · 58/100 · Trust C
Why
32
Iodine
Thyroid Function and Metabolism
Situational ROI · 60/100 · Trust B
Why
The part that's about you

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General verdicts are the floor. Whether something is a waste for YOU depends on your goal, budget, and the rest of your stack.

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